2004指出:“北美的幸福基本上是通过个人成就和

2004指eRS-CoV varies greatly and can be considered a new type of human infectious type B coronavirus. However, the original host of the virus is the same as SARS-CoV, which is a bat. At the same time, the paper found that the molecular channel used by the new coronavirus to enter human cells, that is, the human receptor, may also be the same as SARS virus, which is angiotensin converting enzyme 2 (ACE2). It is worth noting that the paper also disclosed four details: First, the first report of the outbreak was in late December 2019, when most bats in Wuhan were hibernating. Second, not found in the South China Seafood Market。

2004指出:“北美的幸福基本上是通过个人成就和自尊来实

出:“There are bats or bats for sale, but there are many non-aquatic animals including mammals. Third, the gene sequence similarity between 2019-nCoV and its close relatives bat-SL-CoVZC45 and bat-SL-CoVZXC21 is less than 90%, which means these two bat-derived coronaviruses are not 2019-nCoV Direct ancestor. Fourth, in SARS and MERS, bats are their natural hosts, another animal serves as an intermediate host, and humans as the ultimate host. The study found 2019 in all 10 genetic samples taken from patients。

北美的g-nCoV, including 8 complete genomes and 2 partial genomes. The genetic sequences of the samples are almost identical (more than 99.98% of the genetic sequences are identical), which indicates that the virus has only recently infected humans. Professor Shi Weifeng, one of the corresponding authors of the paper, Shandong First Medical University, Shandong Provincial College of Epidemiology and Epidemiology, said that it is worth noting that this study found that the 2019-nCoV virus gene sequences from different patients are almost the same . This finding shows that the separated 2019-nCoV originated from the same source, the propagation time is still very short, and was。

幸福基本0Detected relatively quickly. However, as the virus spreads to more people, it is necessary to constantly monitor the occurrence of mutations. The paper comes from the Chinese Center for Disease Control and Prevention, Shandong University, Shandong First Medical University and Shandong Academy of Medical Sciences, Hubei Provincial Center for Disease Control and Prevention, Shenzhen Huada Yinyuan Medical Technology Co., Ltd., Chinese Academy of Sciences, PLA General Hospital, Wenzhou Medical University, Researcher at the University of Sydney and the First Affiliated Hospital of Shandong First Medical University. Samples were collected from 9 people, 1 person lived in a hotel near the seafood market.。

上是通过3Sequencing was done. The researchers say that the systematic evolutionary analysis of these 2019-nCoV genomes and other coronavirus genomes is to determine the evolutionary history of the virus and help infer its possible origin. To explore the possible receptor binding properties of the virus, the researchers conducted homology modeling. Sample information of nine patients infected with the 2019 new coronavirus 9 patients with viral pneumonia and common respiratory pathogens were negative, and went to at least three hospitals in Wuhan. Eight of them have been to the South China Seafood Market before symptoms appear, and the other (WH04) has not been to the market。

个人成就6Venue, but stayed at a hotel near the market from December 23 to December 27, 2019. Samples of 5 of 9 people (WH19001, WH19002, WH19004, WH19008, YS8011) were collected by the Chinese Center for Disease Control (CDC). The CDC tested the samples and were negative for all common respiratory pathogens screened. The samples of the remaining 4 patients (WH01, WH02, WH03, WH04) were collected by BGI, and the test results showed that they were also negative for common respiratory pathogens. By analyzing samples from 9 patients, the researchers。

和自尊8 complete and 2 partial genome sequences of 2019-nCoV were obtained. These data have been stored in the National Microbiological Data Center of China (registration number NMDC10013002, genome accession numbers NMDC60013002-01 to NMDC60013002-10), and the data of BGI have been saved in the National Gene Bank of China (accession number CNA0007332–35) Based on these genomes, the researchers developed a real-time PCR analysis method, and again tested the original clinical samples of BGI (WH01, WH02, WH0。

3 and WH04) to determine its threshold cycle (Ct) value. The remaining samples were tested by another real-time fluorescent quantitative PCR developed by the Chinese Center for Disease Control and Prevention, with Ct values ​​ranging from 22.85 to 32.41. These results confirm the presence of 2019-nCoV in patients. The virus has only recently infected humans and is genetically similar to the SARS-CoV researchers. The 10 groups of 2019-nCoV genome sequences obtained from 9 patients are highly similar, showing over 99.98% sequence homology. And as a typical RNA virus, the average evolution rate of coronavirus。

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